MS 2: In Silico Models of Coupled Biological Systems

The overarching goal of our project network is the development of detailed in silico models for complex biological systems that couple different scales and heterogeneous data. We concentrate our research on the neuromuscular system and on proliferative and degenerative diseases. We aim to support personalized healthcare and the development of tailor-made biomedical products by using predictive computational models that advance our understanding about the biological system via simulations and model analysis. A particular focus is thereby on models that capture heterogeneity on the cellular level which is related to differences in phenotypes on higher scales, and on building individualized models which allow to derive predictions and hypotheses for the individual patient. This becomes feasible by integrating system-specific data from various sources.